Abstract 4129675: Effective Transcatheter Intracoronary Delivery of mRNA-Lipid Nanoparticle Targeting on The Heart

• Published in: Circulation (New York, N.Y.) Vol. 150; no. Suppl_1; p. A4129675
• Main Authors: Handa, Kazuma, Kawamura, Masashi, Sasai, Masao, Matsuzaki, Takashi, Harada, Akima, Miki, Kenji, Fujimura, Lisa, Saito, Shunsuke, Tsuneda, Ryo, Fujishiro, Anri, Hirano, Kunio, Miyagawa, Shigeru
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 12.11.2024
• Subjects: Coronary circulation; Nucleosides and nucleotides; Ischemia reperfusion; Drug administration

Introduction: mRNA has great potential to provide new medical innovations in the treatment of heart failure. Lipid nanoparticles (LNPs) are an established and effective mRNA delivery system. However, effectively delivering LNPs to the heart remains a significant challenge. We evaluated the efficacy...