Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH 2 terminus of the RLC on β-myosin cross-bridge mechanics

• Published in: Journal of applied physiology (1985) Vol. 117; no. 12; pp. 1471 - 1477
• Main Authors: Farman, Gerrie P., Muthu, Priya, Kazmierczak, Katarzyna, Szczesna-Cordary, Danuta, Moore, Jeffrey R.
• Format: Journal Article
• Language: English
• Published: 15.12.2014

Familial hypertrophic cardiomyopathy (HCM) is associated with mutations in sarcomeric proteins, including the myosin regulatory light chain (RLC). Here we studied the impact of three HCM mutations located in the NH 2 terminus of the RLC on the molecular mechanism of β-myosin heavy chain (MHC) cross-...