Ikaros regulates gene expression programs required for proper BCR-activation in mature B cells

• Published in: The Journal of immunology (1950) Vol. 204; no. 1_Supplement; pp. 218 - 218.2
• Main Authors: Rodriguez, Princess D, Howell, William, Boyd, Joseph, Frietze, Seth, Schjerven, Hilde
• Format: Journal Article
• Language: English
• Published: 01.05.2020

The zinc-finger (ZnF) transcription factor Ikaros (encoded by Ikzf1) plays an essential role in regulating transcriptional programs required for B cell development, as Ikzf1null/null mice do not develop B cells. Ikaros contains two ZnF domains which function in DNA-binding and protein-protein intera...