Prostaglandin E2 Alters the Differentiation and Function of Antigen-Specific T Cells By Targeting the Metabolic Gene Regulatory Network Downstream of mTORC1

• Published in: Blood Vol. 128; no. 22; p. 552
• Main Authors: Herbel, Christoph, Patsoukis, Nikolaos, Weaver, Jessica D, Boussiotis, Vassiliki A.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 02.12.2016

Umbilical cord blood transplantation (UCBT) has extended the availability of hematopoietic stem cell transplantation to patients without compatible adult donors. Studies in zebrafish and mouse models have shown that the prostaglandin compound, 16,16 dimethyl prostaglandin E2 (PGE2), increases HSC nu...