Integrative Genome-Wide Analysis of RNA Binding and Splicing Reveals Complex Loss and Gain of Function Alterations By SRSF2 P95 Mutations in Myelodysplasia

• Published in: Blood Vol. 126; no. 23; p. 141
• Main Authors: Rejeski, Kai, Liang, Yang, Tebaldi, Toma, Stefani, Giovanni, Taylor, Ashley, Maziarz, Jamie, Song, Yuanbin, Balasubramanian, Kunthavai, Vasic, Radovan, Kapetanovic, Edo, Abdel-Wahab, Omar, Pillai, Manoj M, Halene, Stephanie
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 03.12.2015

Specific splicing Factor (SF) mutations are recurrent and mutually exclusive in hematopoietic diseases.Mutations in the splicing factor SRSF2 occur in nearly 40% of patients with CMML, 14% of MDS, and 19% of secondary AML, and portend a poor prognosis. SRSF2 binds to exonic splicing enhancers (ESEs)...