NQO1 Triggers Neutrophil Recruitment and NET formation to Drive Lung Metastasis of Invasive Breast Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 84; no. 21; pp. 3538 - 3555
• Main Authors: Wang, Xinzhi, Qu, Yi, Xu, Qianqian, Jiang, Zeyu, Wang, Hang, Lin, Binyan, Cao, Zehong, Pan, Yuqi, Li, Sheng, Hu, Yili, Yang, Hui, He, Li, Chang, Hang, Hang, Bo, Wen, Hongmei, Wu, Hao, Mao, Jian-Hua
• Format: Journal Article
• Language: English
• Published: United States 04.11.2024

Metastasis to the lungs is a leading cause of death for breast cancer patients. Therefore, effective therapies are urgently needed to prevent and treat breast cancer lung metastasis In this study, we uncovered a mechanism by which NAD(P)H:quinone oxidoreductase 1 (NQO1) orchestrates lung metastasis....