Landscape of KRAS G12C , Associated Genomic Alterations, and Interrelation With Immuno-Oncology Biomarkers in KRAS -Mutated Cancers

• Published in: JCO precision oncology Vol. 6; p. e2100245
• Main Authors: Salem, Mohamed E, El-Refai, Sherif M, Sha, Wei, Puccini, Alberto, Grothey, Axel, George, Thomas J, Hwang, Jimmy J, O'Neil, Bert, Barrett, Alexander S, Kadakia, Kunal C, Musselwhite, Laura W, Raghavan, Derek, Van Cutsem, Eric, Tabernero, Josep, Tie, Jeanne
• Format: Journal Article
• Language: English
• Published: United States 01.05.2022
• Subjects: Acetonitriles; Biomarkers, Tumor - genetics; Carcinoma, Non-Small-Cell Lung - genetics; Female; Genomics; Humans; Kelch-Like ECH-Associated Protein 1; Lung Neoplasms - genetics; Middle Aged; NF-E2-Related Factor 2; Piperazines; Proto-Oncogene Proteins p21(ras) - genetics; Pyrimidines; Retrospective Studies

Promising single-agent activity from sotorasib and adagrasib in -mutant tumors has provided clinical evidence of effective KRAS signaling inhibition. However, comprehensive analysis of -variant prevalence, genomic alterations, and the relationship between and immuno-oncology biomarkers is lacking. R...