Retinal AAV2‐mediated SOCS1 overexpression in the chronic model of experimental autoimmune uveoretinitis

• Published in: Acta ophthalmologica (Oxford, England) Vol. 88; no. s246
• Main Authors: KOCH, P, MAKHOUL, M, ELMALEH, V, LAU‐KILBY, A, DE MAERTELAER, V, DE GRAEF, C, CASPERS, L, BRUYNS, C, TENENBAUM, L, WILLERMAIN, F
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2010

Purpose Activation of retinal cells by IFNγ is required for inflammatory cell recruitment during experimental autoimmune uveitis (EAU) development. IFNγ activates pro‐inflammatory genes transcription but also induces suppressor of cytokine signaling (SOCS) proteins, which negatively regulate IFNγ si...