Evaluating collagen neoepitopes as pharmacodynamic biomarkers of GS-5745, an MMP9 inhibitor, in advanced gastric cancer

• Published in: Journal of clinical oncology Vol. 35; no. 4_suppl; p. 58
• Main Authors: Brachmann, Carrie Baker, Zhang, Yafeng, Zavodovskaya, Marianna, Hu, Jing, Maltzman, Julia D., Smith, Victoria, Xiao, Yuanyuan, Patterson, Scott D
• Format: Journal Article
• Language: English
• Published: 01.02.2017

Abstract only 58 Background: Cancer is characterized by continuous remodeling of the extracellular matrix (ECM) through a process of degradation and replacement of ECM components, such as collagens. Matrix-metalloproteinase 9 (MMP9) is involved in this remodeling and its inhibition is hypothesized t...