Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis

• Published in: PLOS Medicine Vol. 15; no. 6; p. e1002579
• Main Authors: Kloprogge, Frank, Workman, Lesley, Borrmann, Steffen, Tékété, Mamadou, Lefèvre, Gilbert, Hamed, Kamal, Piola, Patrice, Ursing, Johan, Kofoed, Poul Erik, Mårtensson, Andreas, Ngasala, Billy, Björkman, Anders, Ashton, Michael, Friberg Hietala, Sofia, Aweeka, Francesca, Parikh, Sunil, Mwai, Leah, Davis, Timothy M. E., Karunajeewa, Harin, Salman, Sam, Checchi, Francesco, Fogg, Carole, Newton, Paul N., Mayxay, Mayfong, Deloron, Philippe, Faucher, Jean François, Nosten, François, Ashley, Elizabeth A., McGready, Rose, van Vugt, Michele, Proux, Stephane, Price, Ric N., Karbwang, Juntra, Ezzet, Farkad, Bakshi, Rajesh, Stepniewska, Kasia, White, Nicholas J., Guerin, Philippe J., Barnes, Karen I., Tarning, Joel
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science (PLoS) 12.06.2018; Public Library of Science
• Subjects: [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; Age; Antimalarials; Antimalarials - pharmacokinetics; Antimalarials - pharmacology; Antimalarials - therapeutic use; Artemether; Artemether, Lumefantrine Drug Combination; Artemether, Lumefantrine Drug Combination - pharmacokinetics; Artemether, Lumefantrine Drug Combination - pharmacology; Artemether, Lumefantrine Drug Combination - therapeutic use; benflumetol; Bioavailability; Biology and Life Sciences; Care and treatment; Chemical; Child; Child, Preschool; Children; Clinical Medicine; clinical-response; Computer simulation; Development and progression; Dihydroartemisinin; dk/atira/pure/core/subjects/health; Dose-Response Relationship; Dose-Response Relationship, Drug; Drug; Drug dosages; efficacy; Epidemiology; Ethanolamines; Ethanolamines - metabolism; Ethanolamines - pharmacokinetics; Ethanolamines - pharmacology; Exposure; Falciparum/drug therapy; Farmakologi och toxikologi; Female; Fluorenes; Fluorenes - metabolism; Fluorenes - pharmacokinetics; Fluorenes - pharmacology; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi; General & Internal Medicine; Health aspects; Health care; Health Sciences; Hospitals; Humans; Infant; Infant, Newborn; Klinisk medicin; Life Sciences; Lumefantrine; Lumefantrine Drug Combination/pharmacokinetics; Malaria; Malaria, Falciparum; Malaria, Falciparum - drug therapy; Male; Maternal & child health; Medical research; Medicine; Medicine and Health Sciences; Meta-analysis; Models, Chemical; Newborn; Patient outcomes; Patients; Pharmacodynamics; Pharmacokinetics; Pharmacology; Pharmacology and Toxicology; Pharmacy; Plasmodium falciparum; plasmodium-falciparum malaria; population pharmacokinetics; Pregnancy; Pregnant women; Preschool; Public Health, Global Health, Social Medicine and Epidemiology; R; randomized-trial; Research Article; Santé publique et épidémiologie; Schedules; sulfadoxine-pyrimethamine; Systematic review; Tablets; therapeutic response; ugandan children; uncomplicated malaria; Vector-borne diseases; Womens health; Myanmar (Burma); United Kingdom > UK; United States > US; Tanzania; Kenya; Thailand; Switzerland; New Jersey; Sweden; Mali; Guinea Bissau; South Africa; Australia; France; Laos; Western Australia Australia; Germany
• ISSN: 1549-1676; 1549-1277; 1549-1676
• DOI: 10.1371/journal.pmed.1002579

The fixed dose combination of artemether-lumefantrine (AL) is the most widely used treatment for uncomplicated Plasmodium falciparum malaria. Relatively lower cure rates and lumefantrine levels have been reported in young children and in pregnant women during their second and third trimester. The ai...