α 2 -Adrenoceptor Blockade Accelerates the Neurogenic, Neurotrophic, and Behavioral Effects of Chronic Antidepressant Treatment

• Published in: The Journal of neuroscience Vol. 30; no. 3; pp. 1096 - 1109
• Main Authors: Yanpallewar, Sudhirkumar U., Fernandes, Kimberly, Marathe, Swananda V., Vadodaria, Krishna C., Jhaveri, Dhanisha, Rommelfanger, Karen, Ladiwala, Uma, Jha, Shanker, Muthig, Verena, Hein, Lutz, Bartlett, Perry, Weinshenker, David, Vaidya, Vidita A.
• Format: Journal Article
• Language: English
• Published: 20.01.2010

Slow-onset adaptive changes that arise from sustained antidepressant treatment, such as enhanced adult hippocampal neurogenesis and increased trophic factor expression, play a key role in the behavioral effects of antidepressants. α 2 -Adrenoceptors contribute to the modulation of mood and are poten...