Regression of gastric T cell lymphoma with eradication ofHelicobacter pylori

Helicobacter pylori is thought to be important in the pathogenesis of chronic active gastritis, peptic ulceration, gastric adenocarcinoma, and gastric B cell lymphoma of mucosa associated lymphoid tissue. The mechanism of evolution from chronic gastritis to monoclonal B cell proliferation is not kno...

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Bibliographic Details
Published inGut Vol. 48; no. 2; p. 269
Main Authors Bariol, C, Field, A, Vickers, C R, Ward, R
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.02.2001
BMJ Publishing Group LTD
Subjects
Abdomen
Antigens
Biopsy
Celiac disease
Cell growth
Cytotoxicity
Endoscopy
Helicobacter pylori
Lymphocytes
Lymphoma
T cell lymphoma
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Summary:Helicobacter pylori is thought to be important in the pathogenesis of chronic active gastritis, peptic ulceration, gastric adenocarcinoma, and gastric B cell lymphoma of mucosa associated lymphoid tissue. The mechanism of evolution from chronic gastritis to monoclonal B cell proliferation is not known but is thought to be dependent on antigen specific T cells toH pylori and its products. Here, we report a case of gastric T cell lymphoma associated with chronicH pylori gastritis which regressed with eradication of the organism. This is the first report of a gastric T cell lymphoma regressing with H pylorieradication, and suggests a causal link between primary gastric T cell lymphoma and this organism.
Bibliography:ark:/67375/NVC-S0SRPFBH-3
PMID:11156652
href:gutjnl-48-269.pdf
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ISSN:0017-5749
1468-3288
DOI:10.1136/gut.48.2.269