Adenosine Deaminase Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication

• Published in: bioRxiv
• Main Authors: Guan-Ru Liao, Yeu-Yang Tseng, Jing-Yu, Tseng, Fong-Yuan, Lin, Yamada, Yumiko, Hao-Ping, Liu, Chih-Ying Kuan, Wei-Li, Hsu
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 01.11.2018; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Adenosine; Adenosine deaminase; Double-stranded RNA; eIF-2 kinase; Innate immunity; Interferon; Kinases; Microbiology; Orf; Phosphorylation; Protein kinase

Orf virus (ORFV) infects sheep and goats and is also an important zoonotic pathogen. The viral protein OV20.0 has been shown to suppress innate immunity by targeting the double-stranded RNA (dsRNA)-activated protein kinase (PKR) by multiple mechanisms. These mechanisms include a direct interaction w...