Proliferation specific codon usage facilitates oncogene translation

• Published in: bioRxiv
• Main Authors: Benisty, Hannah, Weber, Marc, Hernandez-Alias, Xavier, Schaefer, Martin H, Serrano, Luis
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 11.07.2019; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Cancer; Cancer Biology; Cell proliferation; Codon bias; Mutation; Oncogenes; Translation; tRNA; Tumors; translation; KRAS; tRNA; oncogene; codon usage

Tumors evolve under selection for gene mutations that give a growth advantage to the cancer cell. Intriguingly, some cancer genes are more often found mutated in tumors than their closely related family members. For example, KRAS mutations are more frequently observed in cancer in comparison to HRAS...