FateID infers cell fate bias in multipotent progenitors from single-cell RNA-seq data

• Published in: bioRxiv
• Main Authors: Herman, Josip Stefan, Sagar, Sagar, Grun, Dominic
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 11.11.2017; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Bias; Bioinformatics; Bone marrow; Cell differentiation; Cell fate; Computer applications; Dendritic cells; Gene expression; Hemopoiesis; Lymphocytes B; Ribonucleic acid; RNA

Differentiation of multipotent cells is a complex process governed by interactions of thousands of genes subject to substantial expression fluctuations. Resolving cell state heterogeneity arising during this process requires quantification of gene expression within individual cells. However, computa...