Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germ line transcription in the mouse

• Published in: bioRxiv
• Main Authors: Menon, Debashish U, Shibata, Yoichiro, Mu, Weipeng, Magnuson, Terry
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 26.11.2018; Cold Spring Harbor Laboratory
• Edition: 1.2
• Subjects: Acetylation; BRG1 protein; Chromatin remodeling; Developmental Biology; Gene silencing; Histone H2A; Localization; Lysine; Meiosis; Pluripotency; Polycomb group proteins; Promoters; Sex chromosomes; Spermatocytes; Spermatogenesis; Transcription; Ubiquitin; Ubiquitin-protein ligase; Ubiquitination; SCML2; BRG1; transcriptional regulation; SWI/SNF chromatin remodeling

A deficiency in BRG1, the catalytic subunit of the SWI/SNF chromatin remodeling complex, results in a meiotic arrest during spermatogenesis. Here, we explore the causative mechanisms. BRG1 is preferentially enriched at active promoters of genes essential for spermatogonial pluripotency and meiosis....