Flexible recruitment of memory-based choice representations by human medial-frontal cortex

Decisions in complex environments rely on flexibly utilizing past experience as required by context and instructions. This process depends on medial frontal cortex (MFC) and the medial temporal lobe (MTL), but it remains unknown how these structures interact during memory retrieval. We recorded sing...

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Published inbioRxiv
Main Authors Minxha, Juri, Adolphs, Ralph, Fusi, Stefano, Mamelak, Adam, Rutishauser, Ueli
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 21.11.2019
Cold Spring Harbor Laboratory
Edition1.2
Subjects
Cortex (frontal)
Cortex (temporal)
Decision making
Frequency dependence
Neurons
Neuroscience
Temporal lobe
Theta rhythms
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ISSN2692-8205
2692-8205
DOI10.1101/809673

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Abstract Decisions in complex environments rely on flexibly utilizing past experience as required by context and instructions. This process depends on medial frontal cortex (MFC) and the medial temporal lobe (MTL), but it remains unknown how these structures interact during memory retrieval. We recorded single neurons in MFC and MTL while human subjects switched between making memory and categorization-based decisions. Here we show that MFC rapidly implements changing task demands by utilizing different subspaces of neural activity during different types of decisions. Choices requiring memory retrieval selectively engaged phase-locking between theta-frequency band oscillations in MTL and MFC neurons. Choice neurons signaled decisions independent of output modality. In contrast, no effect of task demands was seen locally in the MTL. This work reveals a mechanism for selectively engaging memory retrieval and shows that unlike perceptual decision-making, memory-related information is only represented in frontal cortex when choices require it. Footnotes * We have added a state-space analysis of the choice dynamics in the medial frontal cortex.
AbstractList Decisions in complex environments rely on flexibly utilizing past experience as required by context and instructions. This process depends on medial frontal cortex (MFC) and the medial temporal lobe (MTL), but it remains unknown how these structures interact during memory retrieval. We recorded single neurons in MFC and MTL while human subjects switched between making memory and categorization-based decisions. Here we show that MFC rapidly implements changing task demands by utilizing different subspaces of neural activity during different types of decisions. Choices requiring memory retrieval selectively engaged phase-locking between theta-frequency band oscillations in MTL and MFC neurons. Choice neurons signaled decisions independent of output modality. In contrast, no effect of task demands was seen locally in the MTL. This work reveals a mechanism for selectively engaging memory retrieval and shows that unlike perceptual decision-making, memory-related information is only represented in frontal cortex when choices require it. Footnotes * We have added a state-space analysis of the choice dynamics in the medial frontal cortex.
Decisions in complex environments rely on flexibly utilizing past experience as required by context and instructions1. This process depends on the medial frontal cortex (MFC) and the medial temporal lobe (MTL)2-5, but it remains unknown how these structures jointly implement flexible memory retrieval6,7. We recorded single neurons in MFC and MTL while human subjects switched8 between making memory- and categorization-based decisions9,10. Here we show that MFC rapidly implements changing task demands by utilizing different subspaces of neural activity during different types of decisions. In contrast, no effect of task demands was seen in the MTL. Choices requiring memory retrieval selectively engaged phase-locking of MFC neurons to field potentials in the theta-frequency band in the MTL. Choice-selective neurons in MFC signaled abstract yes-no decisions independent of behavioral response modality (button press or saccade). These findings reveal a novel mechanism for flexibly and selectively engaging memory retrieval11-14 and show that unlike perceptual decision-making15, memory-related information is only represented in frontal cortex when choices require it.
Author Fusi, Stefano
Mamelak, Adam
Rutishauser, Ueli
Adolphs, Ralph
Minxha, Juri
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Snippet Decisions in complex environments rely on flexibly utilizing past experience as required by context and instructions. This process depends on medial frontal...
Decisions in complex environments rely on flexibly utilizing past experience as required by context and instructions1. This process depends on the medial...
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SubjectTerms Cortex (frontal)
Cortex (temporal)
Decision making
Frequency dependence
Neurons
Neuroscience
Temporal lobe
Theta rhythms
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Title Flexible recruitment of memory-based choice representations by human medial-frontal cortex
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https://www.biorxiv.org/content/10.1101/809673
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