Fibrocyte accumulation in bronchi: a cellular hallmark of COPD

• Published in: bioRxiv
• Main Authors: Dupin, Isabelle, Thumerel, Matthieu, Maurat, Elise, Coste, Florence, Begueret, Hugues, Trian, Thomas, Montaudon, Michel, Marthan, Roger, Pierre-Olivier Girodet, Berger, Patrick
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 23.10.2018; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Bone marrow; Bronchus; CD45 antigen; Chronic obstructive pulmonary disease; Computed tomography; Image processing; Lung diseases; Lungs; Obstructive lung disease; Patients; Physiology; Stroma; Surgery; Thoracic surgery; Thorax; lung function; away remodeling; fibrocytes; CT scan; COPD

Background: The remodeling mechanism and cellular players causing persistent airflow limitation in chronic obstructive pulmonary disease (COPD) remain largely elusive. We have recently demonstrated that circulating fibrocytes, a rare population of fibroblast-like cells produced by the bone marrow st...