Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus

• Published in: BMC evolutionary biology Vol. 10; no. 1; p. 253
• Main Authors: Wong, Emily HM, Smith, David K, Rabadan, Raul, Peiris, Malik, Poon, Leo LM
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.08.2010; BioMed Central; BMC
• Subjects: Amino acids; Analysis; Avian flu; Avian influenza virus; Avian influenza viruses; Bias; Cluster Analysis; Codon; Disease control; Evolution; Evolution, Molecular; Evolutionary genetics; Gene expression; Genes; Genes, Viral; Genetic aspects; Genome, Viral; Genomes; Health aspects; Host selection; Influenza; Influenza A; Influenza A virus; Influenza A virus - genetics; Influenza A Virus, H5N1 Subtype - genetics; Microbiology; Morbidity; Mutation; Orthomyxoviridae; Pandemics; Proteins; RNA, Viral - genetics; Segments; Sequence Analysis, RNA; Studies; Trends; Viruses

The influenza A virus is an important infectious cause of morbidity and mortality in humans and was responsible for 3 pandemics in the 20th century. As the replication of the influenza virus is based on its host's machinery, codon usage of its viral genes might be subject to host selection pres...