Nucleotide dependency analysis of DNA language models reveals genomic functional elements

• Published in: bioRxiv
• Main Authors: Tomaz da Silva, Pedro, Karollus, Alexander, Hingerl, Johannes, Galindez, Gihanna, Wagner, Nils, Hernandez-Alias, Xavier, Incarnato, Danny, Gagneur, Julien
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Laboratory 27.07.2024
• Edition: 1.1
• Subjects: Genomics

Deciphering how nucleotides in genomes encode regulatory instructions and molecular machines is a long-standing goal in biology. DNA language models (LMs) implicitly capture functional elements and their organization from genomic sequences alone by modeling probabilities of each nucleotide given its...