Proteome profiling of nasopharynx reveals pathophysiological signature of COVID-19 disease severity

• Published in: bioRxiv
• Main Authors: Ooi, Amanda, Esau, Luke E., Pugachev, Artyom, Groen, Arnoud, Mfarrej, Sara, Salunke, Rahul P., Subudhi, Amit K., Ben-Rached, Fathia, Alofi, Fadwa, Alsomali, Afrah, Alquthami, Khaled, Khogeer, Asim, Hashem, Anwar M., Almontashiri, Naif, Magistretti, Pierre J., Hala, Sharif, Pain, Arnab
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Laboratory 10.07.2023
• Edition: 1.1
• Subjects: Immunology; COVID-19 host nasopharynx/ innate immune system/ interferon signaling/ oxidative stress/ retinol metabolism

An aberrant innate immune system caused by the beta coronavirus SARS-CoV-2 is a characteristic manifestation of severe coronavirus disease 2019 (COVID-19). Here, we performed proteome profiling of nasopharyngeal (NP) swabs from 273 hospitalized patients with mild and severe COVID-19 symptoms, includ...