p53 mediated regulation of LINE1 retrotransposition derived R-loops

• Published in: bioRxiv
• Main Authors: Paul, Pratyashaa, Kumar, Arun, De, Astik Kumar, Parida, Ankita Subhadarsani, Bhadke, Gauri, Khatua, Satyajeet, Pattanayak, Fizalin, Tiwari, Bhavana
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Laboratory 20.08.2024
• Edition: 1.3
• Subjects: Cancer Biology; Cis R-loop; Trans R-loop; Keywords; Transposons; RNA-DNA hybrids; HDAC inhibitors; R-loops; L1/LINE1; p53

Long Interspersed Nuclear Element 1 (LINE1/L1) retrotransposons, comprising around 17% of the human genome, typically remain quiescent in healthy somatic cells but become activated in various cancer types. Our recent investigation reveals that p53 silences L1 transposons in human somatic cells, pote...