Translational repression of viral RNA mediates arbovirus persistence in mosquitoes

• Published in: bioRxiv
• Main Authors: Talló-Parra, Marc, Puig-Torrents, Mireia, Pérez-Vilaró, Gemma, Pons, Sol Ribó, Hernández-Alias, Xavier, Mantica, Federica, Irimia, Manuel, Serrano, Luis, Díez, Juana
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Laboratory 10.07.2025
• Edition: 1.1
• Subjects: Microbiology

Persistent infection of mosquito cells is essential for the transmission of arboviruses, yet how these viruses produce sufficient progeny without compromising host cell fitness remains unclear. Arbovirus genomes exhibit suboptimal codon usage for both human and mosquito hosts, raising questions abou...