Adolescent female rats undergo full systems consolidation of an aversive memory, while males of the same age fail to discriminate contexts

• Published in: bioRxiv
• Main Authors: Crestani, Ana P., Lotz, Fernanda N., Casagrande, Mirelle A., Popik, Bruno, Guerra, Kétlyn T. K., de Oliveira Alvares, Lucas, Quillfeldt, Jorge A.
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Laboratory 15.09.2021
• Edition: 1.2
• Subjects: Neuroscience; context discrimination; systems consolidation; sex hormones; hippocampus; fear memory generalization

Generalization is an adaptive process that allows animals to deal with threatening circumstances similar to prior experiences. Systems consolidation is a time-dependent process in which memory loses it precision concomitantly with reorganizational changes in the brain structures that support memory...