Genes optimized by evolution for accurate and fast translation encode in Archaea and Bacteria a broad and characteristic spectrum of protein functions

• Published in: BMC genomics Vol. 11; no. 1; p. 617
• Main Authors: von Mandach, Conrad, Merkl, Rainer
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.11.2010; BioMed Central; BMC
• Subjects: Aminoacyl-tRNA synthetases; Archaea - genetics; Archaea - growth & development; Archaea - metabolism; Archaeal Proteins - genetics; Bacteria; Bacteria - genetics; Bacteria - growth & development; Bacteria - metabolism; Bacterial Proteins - genetics; Bias; Biological products; Codon; Codon - genetics; Colleges & universities; Computer science; Ecosystem; Efficiency; Evolution, Molecular; Genes; Genetic aspects; Genetic translation; Genome, Archaeal - genetics; Genome, Bacterial - genetics; Genomes; Genomics; Membrane proteins; Metabolic Networks and Pathways - genetics; Microbiology; Physiological aspects; Proteases; Protein biosynthesis; Protein Biosynthesis - genetics; Protein folding; Protein synthesis; RNA, Transfer - genetics; Species Specificity; Time Factors; Transfer RNA; Germany

In many microbial genomes, a strong preference for a small number of codons can be observed in genes whose products are needed by the cell in large quantities. This codon usage bias (CUB) improves translational accuracy and speed and is one of several factors optimizing cell growth. Whereas CUB and...