An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels

• Published in: BMC genetics Vol. 10; no. 1; p. 39
• Main Authors: Nassir, Rami, Kosoy, Roman, Tian, Chao, White, Phoebe A, Butler, Lesley M, Silva, Gabriel, Kittles, Rick, Alarcon-Riquelme, Marta E, Gregersen, Peter K, Belmont, John W, De La Vega, Francisco M, Seldin, Michael F
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.07.2009; BioMed Central; BMC
• Subjects: African Continental Ancestry Group - genetics; Asian Americans; Asian Continental Ancestry Group - genetics; Biologi; Biological diversity; Biology; Cluster Analysis; Data processing; European Continental Ancestry Group - genetics; Genetic Markers; Genetics; Genetics, Population; Genome, Human; Genomes; Genotype; Genotypes; Humans; Minority & ethnic groups; NATURAL SCIENCES; NATURVETENSKAP; Polymorphism, Single Nucleotide; Population genetics; Population studies; Principal Component Analysis; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Studies; United States

Case-control genetic studies of complex human diseases can be confounded by population stratification. This issue can be addressed using panels of ancestry informative markers (AIMs) that can provide substantial population substructure information. Previously, we described a panel of 128 SNP AIMs th...