Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways

• Published in: BMC cancer Vol. 11; no. 1; p. 388
• Main Authors: Pickhard, Anja C, Margraf, Johanna, Knopf, Andreas, Stark, Thomas, Piontek, Guido, Beck, Carolin, Boulesteix, Anne-Laure, Scherer, Elias Q, Pigorsch, Steffi, Schlegel, Jürgen, Arnold, Wolfgang, Reiter, Rudolf
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.09.2011; BioMed Central; BMC
• Subjects: Apoptosis; Cancer; Cancer therapies; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - enzymology; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - radiotherapy; Cell Line, Tumor; Cell Movement - drug effects; Cell Movement - radiation effects; Chemotherapy; Colleges & universities; Dose-Response Relationship, Radiation; Epidermal Growth Factor - metabolism; ErbB Receptors - antagonists & inhibitors; ErbB Receptors - metabolism; Experiments; Flavonoids - pharmacology; Gamma Rays; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - enzymology; Head and Neck Neoplasms - pathology; Head and Neck Neoplasms - radiotherapy; Humans; Kinases; MAP Kinase Kinase 1 - metabolism; MAP Kinase Signaling System; Otolaryngology; Phosphatidylinositol 3-Kinases - metabolism; Quinazolines - pharmacology; Radiation therapy; Signal Transduction - drug effects; Sirolimus - pharmacology; Squamous Cell Carcinoma of Head and Neck; Surgery; TOR Serine-Threonine Kinases - metabolism; Tyrphostins - pharmacology; Germany

Recently it has been shown that radiation induces migration of glioma cells and facilitates a further spread of tumor cells locally and systemically. The aim of this study was to evaluate whether radiotherapy induces migration in head and neck squamous cell carcinoma (HNSCC). A further aim was to in...