Characterization of murine macrophages from bone marrow, spleen and peritoneum

Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular source...

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Published inBMC immunology Vol. 14; no. 1; p. 6
Main Authors Wang, Changqi, Yu, Xiao, Cao, Qi, Wang, Ya, Zheng, Guoping, Tan, Thian Kui, Zhao, Hong, Zhao, Ye, Wang, Yiping, Harris, David CH
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 05.02.2013
BioMed Central
BMC
Subjects
Animals
Antigen Presentation - immunology
Bone marrow
Bone Marrow Cells - cytology
Bone morphogenetic proteins
CD4-Positive T-Lymphocytes - immunology
Cell Membrane - metabolism
Cell Proliferation
Cell Shape
Cells, Cultured
Comparative analysis
Cytokines - genetics
Cytokines - metabolism
Dextrans - metabolism
Flow Cytometry
Fluorescein-5-isothiocyanate - analogs & derivatives
Fluorescein-5-isothiocyanate - metabolism
Gene Expression Regulation
Genotype & phenotype
Immune response
Lymphocyte Activation - immunology
Macrophage
Macrophages
Macrophages - cytology
Macrophages - immunology
Macrophages, Peritoneal - cytology
Male
Mice
Mice, Inbred BALB C
Nitric oxide
Peritoneum
Phagocytosis - immunology
Phenotype
Physiological aspects
Proteins
RNA, Messenger - genetics
RNA, Messenger - metabolism
Rodents
Spleen
Spleen - cytology
Statistical methods
Studies
Transforming growth factors
Australia
Online AccessGet full text
ISSN1471-2172
1471-2172
DOI10.1186/1471-2172-14-6

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Abstract Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain unclear. In this study, the features of murine macrophages from bone marrow, spleen and peritoneum were compared. We found that peritoneal macrophages (PMs) appear to be more mature than bone marrow derived macrophages (BMs) and splenic macrophages (SPMs) based on their morphology and surface molecular characteristics. BMs showed the strongest capacity for both proliferation and phagocytosis among the three populations of macrophage. Under resting conditions, SPMs maintained high levels of pro-inflammatory cytokines expression (IL-6, IL-12 and TNF-α), whereas BMs produced high levels of suppressive cytokines (IL-10 and TGF-β). However, SPMs activated with LPS not only maintained higher levels of (IL-6, IL-12 and TNF-α) than BMs or PMs, but also maintained higher levels of IL-10 and TGF-β. Our results show that BMs, SPMs and PMs are distinct populations with different biological functions, providing clues to guide their further experimental or therapeutic use.
AbstractList Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain unclear. In this study, the features of murine macrophages from bone marrow, spleen and peritoneum were compared. We found that peritoneal macrophages (PMs) appear to be more mature than bone marrow derived macrophages (BMs) and splenic macrophages (SPMs) based on their morphology and surface molecular characteristics. BMs showed the strongest capacity for both proliferation and phagocytosis among the three populations of macrophage. Under resting conditions, SPMs maintained high levels of pro-inflammatory cytokines expression (IL-6, IL-12 and TNF-[alpha]), whereas BMs produced high levels of suppressive cytokines (IL-10 and TGF-[beta]). However, SPMs activated with LPS not only maintained higher levels of (IL-6, IL-12 and TNF-[alpha]) than BMs or PMs, but also maintained higher levels of IL-10 and TGF-[beta]. Our results show that BMs, SPMs and PMs are distinct populations with different biological functions, providing clues to guide their further experimental or therapeutic use.
Doc number: 6 Abstract Background: Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain unclear. In this study, the features of murine macrophages from bone marrow, spleen and peritoneum were compared. Results: We found that peritoneal macrophages (PMs) appear to be more mature than bone marrow derived macrophages (BMs) and splenic macrophages (SPMs) based on their morphology and surface molecular characteristics. BMs showed the strongest capacity for both proliferation and phagocytosis among the three populations of macrophage. Under resting conditions, SPMs maintained high levels of pro-inflammatory cytokines expression (IL-6, IL-12 and TNF-α), whereas BMs produced high levels of suppressive cytokines (IL-10 and TGF-β). However, SPMs activated with LPS not only maintained higher levels of (IL-6, IL-12 and TNF-α) than BMs or PMs, but also maintained higher levels of IL-10 and TGF-β. Conclusions: Our results show that BMs, SPMs and PMs are distinct populations with different biological functions, providing clues to guide their further experimental or therapeutic use.
Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain unclear. In this study, the features of murine macrophages from bone marrow, spleen and peritoneum were compared.BACKGROUNDMacrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain unclear. In this study, the features of murine macrophages from bone marrow, spleen and peritoneum were compared.We found that peritoneal macrophages (PMs) appear to be more mature than bone marrow derived macrophages (BMs) and splenic macrophages (SPMs) based on their morphology and surface molecular characteristics. BMs showed the strongest capacity for both proliferation and phagocytosis among the three populations of macrophage. Under resting conditions, SPMs maintained high levels of pro-inflammatory cytokines expression (IL-6, IL-12 and TNF-α), whereas BMs produced high levels of suppressive cytokines (IL-10 and TGF-β). However, SPMs activated with LPS not only maintained higher levels of (IL-6, IL-12 and TNF-α) than BMs or PMs, but also maintained higher levels of IL-10 and TGF-β.RESULTSWe found that peritoneal macrophages (PMs) appear to be more mature than bone marrow derived macrophages (BMs) and splenic macrophages (SPMs) based on their morphology and surface molecular characteristics. BMs showed the strongest capacity for both proliferation and phagocytosis among the three populations of macrophage. Under resting conditions, SPMs maintained high levels of pro-inflammatory cytokines expression (IL-6, IL-12 and TNF-α), whereas BMs produced high levels of suppressive cytokines (IL-10 and TGF-β). However, SPMs activated with LPS not only maintained higher levels of (IL-6, IL-12 and TNF-α) than BMs or PMs, but also maintained higher levels of IL-10 and TGF-β.Our results show that BMs, SPMs and PMs are distinct populations with different biological functions, providing clues to guide their further experimental or therapeutic use.CONCLUSIONSOur results show that BMs, SPMs and PMs are distinct populations with different biological functions, providing clues to guide their further experimental or therapeutic use.
Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain unclear. In this study, the features of murine macrophages from bone marrow, spleen and peritoneum were compared. We found that peritoneal macrophages (PMs) appear to be more mature than bone marrow derived macrophages (BMs) and splenic macrophages (SPMs) based on their morphology and surface molecular characteristics. BMs showed the strongest capacity for both proliferation and phagocytosis among the three populations of macrophage. Under resting conditions, SPMs maintained high levels of pro-inflammatory cytokines expression (IL-6, IL-12 and TNF-α), whereas BMs produced high levels of suppressive cytokines (IL-10 and TGF-β). However, SPMs activated with LPS not only maintained higher levels of (IL-6, IL-12 and TNF-α) than BMs or PMs, but also maintained higher levels of IL-10 and TGF-β. Our results show that BMs, SPMs and PMs are distinct populations with different biological functions, providing clues to guide their further experimental or therapeutic use.
Background: Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain unclear. In this study, the features of murine macrophages from bone marrow, spleen and peritoneum were compared. Results: We found that peritoneal macrophages (PMs) appear to be more mature than bone marrow derived macrophages (BMs) and splenic macrophages (SPMs) based on their morphology and surface molecular characteristics. BMs showed the strongest capacity for both proliferation and phagocytosis among the three populations of macrophage. Under resting conditions, SPMs maintained high levels of pro-inflammatory cytokines expression (IL-6, IL-12 and TNF-[alpha]), whereas BMs produced high levels of suppressive cytokines (IL-10 and TGF-[beta]). However, SPMs activated with LPS not only maintained higher levels of (IL-6, IL-12 and TNF-[alpha]) than BMs or PMs, but also maintained higher levels of IL-10 and TGF-[beta]. Conclusions: Our results show that BMs, SPMs and PMs are distinct populations with different biological functions, providing clues to guide their further experimental or therapeutic use.
BACKGROUND: Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain unclear. In this study, the features of murine macrophages from bone marrow, spleen and peritoneum were compared. RESULTS: We found that peritoneal macrophages (PMs) appear to be more mature than bone marrow derived macrophages (BMs) and splenic macrophages (SPMs) based on their morphology and surface molecular characteristics. BMs showed the strongest capacity for both proliferation and phagocytosis among the three populations of macrophage. Under resting conditions, SPMs maintained high levels of pro-inflammatory cytokines expression (IL-6, IL-12 and TNF-α), whereas BMs produced high levels of suppressive cytokines (IL-10 and TGF-β). However, SPMs activated with LPS not only maintained higher levels of (IL-6, IL-12 and TNF-α) than BMs or PMs, but also maintained higher levels of IL-10 and TGF-β. CONCLUSIONS: Our results show that BMs, SPMs and PMs are distinct populations with different biological functions, providing clues to guide their further experimental or therapeutic use.
Abstract Background Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain unclear. In this study, the features of murine macrophages from bone marrow, spleen and peritoneum were compared. Results We found that peritoneal macrophages (PMs) appear to be more mature than bone marrow derived macrophages (BMs) and splenic macrophages (SPMs) based on their morphology and surface molecular characteristics. BMs showed the strongest capacity for both proliferation and phagocytosis among the three populations of macrophage. Under resting conditions, SPMs maintained high levels of pro-inflammatory cytokines expression (IL-6, IL-12 and TNF-α), whereas BMs produced high levels of suppressive cytokines (IL-10 and TGF-β). However, SPMs activated with LPS not only maintained higher levels of (IL-6, IL-12 and TNF-α) than BMs or PMs, but also maintained higher levels of IL-10 and TGF-β. Conclusions Our results show that BMs, SPMs and PMs are distinct populations with different biological functions, providing clues to guide their further experimental or therapeutic use.
Background Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been performed on macrophages derived from bone marrow, spleen and peritoneum. However, differences among macrophages from these particular sources remain unclear. In this study, the features of murine macrophages from bone marrow, spleen and peritoneum were compared. Results We found that peritoneal macrophages (PMs) appear to be more mature than bone marrow derived macrophages (BMs) and splenic macrophages (SPMs) based on their morphology and surface molecular characteristics. BMs showed the strongest capacity for both proliferation and phagocytosis among the three populations of macrophage. Under resting conditions, SPMs maintained high levels of pro-inflammatory cytokines expression (IL-6, IL-12 and TNF-[alpha]), whereas BMs produced high levels of suppressive cytokines (IL-10 and TGF-[beta]). However, SPMs activated with LPS not only maintained higher levels of (IL-6, IL-12 and TNF-[alpha]) than BMs or PMs, but also maintained higher levels of IL-10 and TGF-[beta]. Conclusions Our results show that BMs, SPMs and PMs are distinct populations with different biological functions, providing clues to guide their further experimental or therapeutic use. Keywords: Macrophage, Bone marrow, Spleen, Peritoneum
ArticleNumber 6
Audience Academic
Author Wang, Changqi
Tan, Thian Kui
Harris, David CH
Zhao, Ye
Cao, Qi
Wang, Ya
Zheng, Guoping
Yu, Xiao
Wang, Yiping
Zhao, Hong
AuthorAffiliation 1 Centre for Transplant and Renal Research at Westmead, Sydney, NSW, Australia
3 Department of Biochemistry and Molecular Biology, Shanxi Medical University, Shanxi, PR China
2 Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
AuthorAffiliation_xml – name: 3 Department of Biochemistry and Molecular Biology, Shanxi Medical University, Shanxi, PR China
– name: 2 Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
– name: 1 Centre for Transplant and Renal Research at Westmead, Sydney, NSW, Australia
Author_xml – sequence: 1
  givenname: Changqi
  surname: Wang
  fullname: Wang, Changqi
– sequence: 2
  givenname: Xiao
  surname: Yu
  fullname: Yu, Xiao
– sequence: 3
  givenname: Qi
  surname: Cao
  fullname: Cao, Qi
– sequence: 4
  givenname: Ya
  surname: Wang
  fullname: Wang, Ya
– sequence: 5
  givenname: Guoping
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  fullname: Zheng, Guoping
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  givenname: Thian Kui
  surname: Tan
  fullname: Tan, Thian Kui
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  fullname: Zhao, Hong
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  surname: Zhao
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– sequence: 9
  givenname: Yiping
  surname: Wang
  fullname: Wang, Yiping
– sequence: 10
  givenname: David CH
  surname: Harris
  fullname: Harris, David CH
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23384230$$D View this record in MEDLINE/PubMed
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Snippet Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies have been...
Background Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental studies...
Doc number: 6 Abstract Background: Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date,...
Background: Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental...
BACKGROUND: Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most experimental...
Abstract Background Macrophages have heterogeneous phenotypes and complex functions within both innate and adaptive immune responses. To date, most...
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StartPage 6
SubjectTerms Animals
Antigen Presentation - immunology
Bone marrow
Bone Marrow Cells - cytology
Bone morphogenetic proteins
CD4-Positive T-Lymphocytes - immunology
Cell Membrane - metabolism
Cell Proliferation
Cell Shape
Cells, Cultured
Comparative analysis
Cytokines - genetics
Cytokines - metabolism
Dextrans - metabolism
Flow Cytometry
Fluorescein-5-isothiocyanate - analogs & derivatives
Fluorescein-5-isothiocyanate - metabolism
Gene Expression Regulation
Genotype & phenotype
Immune response
Lymphocyte Activation - immunology
Macrophage
Macrophages
Macrophages - cytology
Macrophages - immunology
Macrophages, Peritoneal - cytology
Male
Mice
Mice, Inbred BALB C
Nitric oxide
Peritoneum
Phagocytosis - immunology
Phenotype
Physiological aspects
Proteins
RNA, Messenger - genetics
RNA, Messenger - metabolism
Rodents
Spleen
Spleen - cytology
Statistical methods
Studies
Transforming growth factors
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Title Characterization of murine macrophages from bone marrow, spleen and peritoneum
URI https://www.ncbi.nlm.nih.gov/pubmed/23384230
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http://dx.doi.org/10.1186/1471-2172-14-6
https://pubmed.ncbi.nlm.nih.gov/PMC3574850
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Volume 14
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