Citrulline/malate promotes aerobic energy production in human exercising muscle

• Published in: British journal of sports medicine Vol. 36; no. 4; pp. 282 - 289
• Main Authors: Bendahan, D, Mattei, J P, Ghattas, B, Confort-Gouny, S, Le Guern, M E, Cozzone, P J
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine 01.08.2002; BMJ Publishing Group Ltd; BMJ Publishing Group LTD; BMJ Publishing Group; BMJ Group
• Subjects: 31P magnetic resonance spectroscopy; Adenosine triphosphatase; Adult; Analysis of Variance; anaplerosis; Applications; Bioenergetics; Citrulline; Citrulline - analogs & derivatives; Citrulline - pharmacology; citrulline/malate; Drug therapy; energetics; energy cost; Energy metabolism; Exercise; Family medical history; Fatigue; Fourier Analysis; Human health and pathology; Humans; Life Sciences; Linear Models; Magnetic Resonance Spectroscopy; Malates - pharmacology; Male; Metabolism; MRS; Muscle Fatigue - drug effects; Muscle, Skeletal - metabolism; Muscles; Muscular system; Original; PCr; phosphocreatine; Physical fitness; Physiological aspects; skeletal muscle; Spectrum analysis; Sports medicine; Statistics; TCA; tricarboxylic acid cycle; France

Background: Previous studies have shown an antiasthenic effect of citrulline/malate (CM) but the mechanism of action at the muscular level remains unknown. Objective: To investigate the effects of CM supplementation on muscle energetics. Methods: Eighteen men complaining of fatigue but with no docum...