Comparison of mouse mammary gland imaging techniques and applications: Reflectance confocal microscopy, GFP Imaging, and ultrasound

• Published in: BMC cancer Vol. 8; no. 1; p. 21
• Main Authors: Tilli, Maddalena T, Parrish, Angela R, Cotarla, Ion, Jones, Laundette P, Johnson, Michael D, Furth, Priscilla A
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.01.2008; BioMed Central; BMC
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - diagnostic imaging; Animals; Breast cancer; Care and treatment; Confocal microscopy; Diagnosis; Female; Green Fluorescent Proteins - genetics; Mammary Glands, Animal - anatomy & histology; Mammary Glands, Animal - transplantation; Mammary Neoplasms, Experimental - diagnosis; Mammary Neoplasms, Experimental - diagnostic imaging; Methods; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Microscopy, Fluorescence - methods; Microscopy, Interference; Organ Culture Techniques; Transplantation, Homologous; Ultrasonography; Ultrasound imaging; United States

Genetically engineered mouse models of mammary gland cancer enable the in vivo study of molecular mechanisms and signaling during development and cancer pathophysiology. However, traditional whole mount and histological imaging modalities are only applicable to non-viable tissue. We evaluated three...