Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury

• Published in: Journal of neuroinflammation Vol. 9; no. 1; p. 43
• Main Authors: Byrnes, Kimberly R, Loane, David J, Stoica, Bogdan A, Zhang, Jiangyang, Faden, Alan I
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.02.2012; BioMed Central; BMC
• Subjects: Anatomy & physiology; Anesthesiology; Animal cognition; Animals; Apoptosis; Brain; Brain damage; Brain injuries; Brain Injuries - complications; Calcium-Binding Proteins - metabolism; Cell receptors; Cognition Disorders - etiology; Degeneration; delayed treatment; Diffusion Tensor Imaging; Disease Models, Animal; Ectodysplasins - metabolism; Encephalitis - drug therapy; Encephalitis - etiology; Encephalitis - metabolism; Excitatory Amino Acid Agonists - therapeutic use; Excitatory Amino Acid Antagonists - pharmacology; Gene expression; Gene Expression Regulation - drug effects; Glutamate; Glycine - analogs & derivatives; Glycine - therapeutic use; Health sciences; Hippocampus - pathology; House mouse; Injuries; Magnetic Resonance Imaging; Male; metabotropic glutamate receptor 5; Mice; Mice, Inbred C57BL; Microfilament Proteins - metabolism; microglia; Microglia - drug effects; Microglia - metabolism; Motion detectors; Movement Disorders - etiology; Nervous system; Neurodegeneration; Neurodegenerative Diseases - drug therapy; Neurodegenerative Diseases - etiology; Neurodegenerative Diseases - metabolism; Neurons; Neurons - pathology; neuroprotection; Neurosciences; Niacinamide; Nitric oxide; Oxidases; Phenylacetates - therapeutic use; Phosphates; Physiological aspects; Purines; Pyridine; Pyridines - pharmacology; Receptor, Metabotropic Glutamate 5; Receptors, Immunologic - metabolism; Receptors, Metabotropic Glutamate - metabolism; Recovery of Function - drug effects; Rodents; Statistics, Nonparametric; Studies; Thiazoles - pharmacology; Time Factors; Traumatic brain injury; United States

Traumatic brain injury initiates biochemical processes that lead to secondary neurodegeneration. Imaging studies suggest that tissue loss may continue for months or years after traumatic brain injury in association with chronic microglial activation. Recently we found that metabotropic glutamate rec...