Metabolic pathway engineering based on metabolomics confers acetic and formic acid tolerance to a recombinant xylose-fermenting strain of Saccharomyces cerevisiae - Hasunuma, Tomohisa; Sanda, Tomoya; Yamada, Ryosuke; Yoshimura, Kazuya; Ishii, Jun; Kondo, Akihiko (Microbial cell factories, 2011)
Keywords: Acetic acid; Acetic Acid - pharmacology; Acids; Biofuels; Brewer's yeast; Drug tolerance; Enzymes; Ethanol; Ethanol - metabolism; Fermentation; Formates - pharmacology; Formic acid; Genetic aspects; Genetic Engineering; Hydrolysates; Hydrolysis; lignocellulose; metabolic engineering; Metabolic Networks and Pathways; Metabolic pathways; Metabolites; Metabolome; Metabolomics; Microbiology; Organic acids; Pentose Phosphate Pathway; Physiological aspects; Saccharomyces cerevisiae; Saccharomyces cerevisiae - enzymology; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Solubilization; Stress; Toxicity; Transaldolase; Transaldolase - genetics; Transaldolase - metabolism; Transketolase; Transketolase - genetics; Transketolase - metabolism; Xylose; Xylose - metabolism; Yeasts; Japan