Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver

• Published in: Particle and fibre toxicology Vol. 9; no. 1; p. 5
• Main Authors: Bourdon, Julie A, Saber, Anne T, Jacobsen, Nicklas R, Jensen, Keld A, Madsen, Anne M, Lamson, Jacob S, Wallin, Håkan, Møller, Peter, Loft, Steffen, Yauk, Carole L, Vogel, Ulla B
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.02.2012; BioMed Central; BMC
• Subjects: Analysis; Animals; Atoms & subatomic particles; Bioassays; Black carbon; Bronchoalveolar Lavage Fluid - cytology; Carbon; Carbon Black; Comet Assay; Deoxyribonucleic acid; DNA; DNA damage; DNA Damage - drug effects; DNA strand breaks; Exposure; Female; Genetic aspects; Genotoxicity; Health sciences; Inflammation; Liver; Liver - immunology; Liver - pathology; Liver - physiopathology; Lung - immunology; Lung - pathology; Lung - physiology; Lungs; Mice; Mice, Inbred C57BL; Nanoparticles; Nanoparticles - chemistry; Occupational Exposure; Outdoor air quality; Oxidative stress; Polycyclic aromatic hydrocarbons; Regression analysis; RNA; Rodents; Soot - pharmacology; Studies; Denmark; Canada

Widespread occupational exposure to carbon black nanoparticles (CBNPs) raises concerns over their safety. CBNPs are genotoxic in vitro but less is known about their genotoxicity in various organs in vivo. We investigated inflammatory and acute phase responses, DNA strand breaks (SB) and oxidatively...