06.07 Disease-inducible interleukin-10 gene therapy suppresses innate cytokine response in the 3d micromass model of the synovial membrane

• Published in: Annals of the rheumatic diseases Vol. 76; no. Suppl 1; p. A62
• Main Authors: Broeren, Mathijs GA, Bennink, Miranda B, Arntz, Onno J, van den Berg, Wim B, van de Loo, Fons AJ
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.03.2017

BackgroundNo disease-modifying drugs are available for osteoarthritis (OA). Although the aetiology is still unknown, inflammation is indicated to be involved in the disease pathogenesis in many patients. Gene therapy can enable transduced joint cells to express an anti-inflammatory biological drug w...