Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain

• Published in: Genome biology Vol. 15; no. 3; p. R49
• Main Authors: Wen, Lu, Li, Xianlong, Yan, Liying, Tan, Yuexi, Li, Rong, Zhao, Yangyu, Wang, Yan, Xie, Jingcheng, Zhang, Yan, Song, Chunxiao, Yu, Miao, Liu, Xiaomeng, Zhu, Ping, Li, Xiaoyu, Hou, Yu, Guo, Hongshan, Wu, Xinglong, He, Chuan, Li, Ruiqiang, Tang, Fuchou, Qiao, Jie
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.03.2014; BioMed Central
• Subjects: 5-Methylcytosine - metabolism; Adult; adults; brain; Brain - embryology; Brain - growth & development; Brain - metabolism; chromatin; CpG Islands; Cytosine - analogs & derivatives; Cytosine - metabolism; DNA Methylation; DNA, Antisense - metabolism; enzymes; epigenetics; Exons; Female; gene expression; Gene Expression Regulation, Developmental; genes; Genome, Human; Histones - genetics; Humans; Introns; Male; regulatory sequences; transcription (genetics); Transcription, Genetic

5-methylcytosine (mC) can be oxidized by the tet methylcytosine dioxygenase (Tet) family of enzymes to 5-hydroxymethylcytosine (hmC), which is an intermediate of mC demethylation and may also be a stable epigenetic modification that influences chromatin structure. hmC is particularly abundant in mam...