MicroRNA-34a functions as an anti-metastatic microRNA and suppresses angiogenesis in bladder cancer by directly targeting CD44

• Published in: Journal of experimental & clinical cancer research Vol. 33; no. 1; p. 779
• Main Authors: Yu, Gan, Yao, Weimin, Xiao, Wei, Li, Heng, Xu, Hua, Lang, Bin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.12.2014; BioMed Central; BMC
• Subjects: Analysis; Angiogenesis; Apoptosis; Biomarkers; Bladder cancer; Bladder cancer cell; Cancer; Cancer therapies; Care and treatment; CD44; Cell growth; Cell Line, Tumor; Chemotherapy; Gene expression; Gene Knockdown Techniques; Health aspects; Humans; Hyaluronan Receptors - genetics; Immunohistochemistry; Kidney cancer; Medical research; Metastasis; Metastatic; MicroRNAs; MicroRNAs - genetics; MicroRNAs - physiology; miR-34a; Neoplasm Metastasis - genetics; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - prevention & control; Prostate cancer; Science; Studies; Tumors; Urinary Bladder Neoplasms - blood supply; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - pathology; Urology

Metastasis have considered as an important clinical obstacle in the treatment of human cancer including bladder cancer. Post-transcriptional regulation has emerged as robust effectors of metastasis. MiRNAs are involved in cancer development and progression, acting as tumor suppressors or oncogenes....