Disturbance of the OPG/RANK/RANKL pathway and systemic inflammation in COPD patients with emphysema and osteoporosis

• Published in: Respiratory research Vol. 12; no. 1; p. 157
• Main Authors: Bai, Peng, Sun, Yongchang, Jin, Jianmin, Hou, Jia, Li, Ran, Zhang, Qing, Wang, Yang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.12.2011; BioMed Central; BMC
• Subjects: Aged; Bone density; Bone mineral density; Bones; chronic obstructive pulmonary disease; cytokine; Cytokines - blood; Development and progression; Emphysema; Emphysema - blood; Emphysema - complications; Emphysema, Pulmonary; Female; Health aspects; Humans; Inflammation; Male; Menopause; OPG/RANK/RANKL; Osteoporosis; Osteoporosis - blood; Osteoporosis - complications; Osteoprotegerin - blood; Physiological aspects; Postmenopausal women; Pulmonary Disease, Chronic Obstructive - blood; Pulmonary Disease, Chronic Obstructive - complications; pulmonary emphysema; RANK Ligand - blood; Receptor Activator of Nuclear Factor-kappa B - blood; Regression analysis; Respiratory function; Risk factors; Signal Transduction; Smokers; Systemic Inflammatory Response Syndrome - blood; Systemic Inflammatory Response Syndrome - complications; Thoracic surgery; Tumor necrosis factor; China

Osteoporosis is one of the systemic features of COPD. A correlation between the emphysema phenotype of COPD and reduced bone mineral density (BMD) is suggested by some studies, however, the mechanisms underlying this relationship are unclear. Experimental studies indicate that IL-1β, IL-6 and TNF-α...