Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories

• Published in: BMC genomics Vol. 9; no. 1; p. 285
• Main Authors: Boedigheimer, Michael J, Wolfinger, Russell D, Bass, Michael B, Bushel, Pierre R, Chou, Jeff W, Cooper, Matthew, Corton, J Christopher, Fostel, Jennifer, Hester, Susan, Lee, Janice S, Liu, Fenglong, Liu, Jie, Qian, Hui-Rong, Quackenbush, John, Pettit, Syril, Thompson, Karol L
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.06.2008; BioMed Central; BMC
• Subjects: Animals; Computational Biology; Databases, Nucleic Acid; Discriminant Analysis; DNA microarrays; Fasting - metabolism; Female; Gene expression; Gene Expression Profiling; Genetic Variation; Health aspects; Kidney - metabolism; Liver - metabolism; Male; Methods; Multivariate Analysis; Oligonucleotide Array Sequence Analysis - statistics & numerical data; Physiological aspects; Principal Component Analysis; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rats, Wistar; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Sex Characteristics; Toxicogenetics - methods; Toxicogenomics; United States

The use of gene expression profiling in both clinical and laboratory settings would be enhanced by better characterization of variance due to individual, environmental, and technical factors. Meta-analysis of microarray data from untreated or vehicle-treated animals within the control arm of toxicog...