Steroid receptor coactivator 1 deficiency increases MMTV-neu mediated tumor latency and differentiation specific gene expression, decreases metastasis, and inhibits response to PPAR ligands

• Published in: BMC cancer Vol. 10; no. 1; p. 629
• Main Authors: Han, Ji Seung, Crowe, David L
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.11.2010; BioMed Central; BMC
• Subjects: Animals; Antineoplastic Agents - pharmacology; Breast cancer; Cancer therapies; Cell Differentiation - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Chromatin Assembly and Disassembly - drug effects; Clofibrate - pharmacology; CREB-Binding Protein - genetics; CREB-Binding Protein - metabolism; Development and progression; Fatty Acids, Unsaturated - pharmacology; Female; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Genetic aspects; Humans; Mammary Neoplasms, Experimental - enzymology; Mammary Neoplasms, Experimental - genetics; Mammary Neoplasms, Experimental - pathology; Mammary Neoplasms, Experimental - prevention & control; Mammary Tumor Virus, Mouse - genetics; Medical research; Mice; Mice, Knockout; Mice, Transgenic; Neoplasm Invasiveness; Nuclear Receptor Coactivator 1 - deficiency; Nuclear Receptor Coactivator 1 - genetics; Peroxisome Proliferator-Activated Receptors - agonists; Peroxisome Proliferator-Activated Receptors - genetics; Peroxisome Proliferator-Activated Receptors - metabolism; Peroxisomes; Physiological aspects; Promoter Regions, Genetic; Proteins; Retinoid X Receptors - agonists; Retinoid X Receptors - genetics; Retinoid X Receptors - metabolism; Rodents; Tetrahydronaphthalenes - pharmacology; Thiazolidinediones - pharmacology; Time Factors; Transcriptional coactivators; Transfection; Tumor Burden - drug effects; Tumors

The peroxisome proliferator activated receptor (PPAR) subgroup of the nuclear hormone receptor superfamily is activated by a variety of natural and synthetic ligands. PPARs can heterodimerize with retinoid X receptors, which have homology to other members of the nuclear receptor superfamily. Ligand...