Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets

• Published in: BMC genomics Vol. 3; no. 1; p. 15
• Main Authors: Mesko, Bertalan, Poliskal, Szilard, Szegedi, Andrea, Szekanecz, Zoltan, Palatka, Karoly, Papp, Maria, Nagy, Laszlo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.05.2010; BioMed Central; BMC
• Subjects: Adult; Anti-inflammatory drugs; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - genetics; Biomarkers - blood; Chronic Disease; Dosage and administration; Drug therapy; Female; Gene Expression; Gene Expression Profiling; Genetic aspects; Genetic markers; Humans; Inflammation; Inflammatory Bowel Diseases - blood; Inflammatory Bowel Diseases - genetics; Leukocytes - metabolism; Male; Messenger RNA; Middle Aged; Physiological aspects; Prognosis; Psoriasis - blood; Psoriasis - genetics; Research article; Hungary

Chronic inflammatory diseases including inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis), psoriasis and rheumatoid arthritis (RA) afflict millions of people worldwide, but their pathogenesis is still not well understood. It is also not well known if distinct changes in g...