Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese

• Published in: BMC cancer Vol. 10; no. 1; p. 456
• Main Authors: Liu, Jie, Song, Bao, Bai, Xueli, Liu, Wenjian, Li, Zengjun, Wang, Jialin, Zheng, Yan, Wang, Zhehai
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.08.2010; BioMed Central; BMC
• Subjects: Aged; Aged, 80 and over; Alleles; Angiogenesis; Case-Control Studies; Deoxyribonucleic acid; DNA; Genes; Genetic aspects; Genetic polymorphisms; Genetic testing; Genotype; Haplotypes; Humans; Interleukin-10; Interleukin-10 - genetics; Male; Middle Aged; Mortality; Oncology; Polymerase Chain Reaction; Polymorphism, Single Nucleotide - genetics; Prognosis; Promoter Regions, Genetic - genetics; Prostate - metabolism; Prostate - pathology; Prostate cancer; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Risk Factors; Statistical analysis; Studies; China

Recent studies identified an increased risk of prostate cancer (PCa) in Caucasian men harboring polymorphisms of genes involved in innate immunity and inflammation. This study was designed to assess whether single nucleotide polymorphisms in the IL-10 promoter play a role in predisposing individuals...