Wnt signal transduction pathway and apoptosis: a review

The association between the wnt signaling pathway and apoptosis has become more firmly established in the recent scientific literature. Many reports indicate that the wnt signaling pathway regulates apoptosis through a variety of mechanisms.The activity of wnt signaling according to specific cellula...

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Bibliographic Details
Published inCancer cell international Vol. 10; no. 1; p. 22
Main Author Pećina-Slaus, Nives
Format Journal Article
LanguageEnglish
Published England BioMed Central 30.06.2010
BioMed Central Ltd
BMC
Subjects
Apoptosis
Cancer
Cellular biology
Genes
Mutation
Proteins
Review
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Summary:The association between the wnt signaling pathway and apoptosis has become more firmly established in the recent scientific literature. Many reports indicate that the wnt signaling pathway regulates apoptosis through a variety of mechanisms.The activity of wnt signaling according to specific cellular environment stimuli can either foster or restrain the processes of apoptosis. Wnt signaling regulates the early and late stages of apoptosis in both development and cellular injury in populations of neurons, endothelial cells, vascular smooth muscle cells and cardiomyocytes.In this review I draw attention to genes and proteins of the wnt signaling pathway involved in apoptosis and describe some of their functional effects.
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ISSN:1475-2867
1475-2867
DOI:10.1186/1475-2867-10-22