The Expression of Spinal Methyl-CpG-Binding Protein 2, DNA Methyltransferases and Histone Deacetylases is Modulated in Persistent Pain States

• Published in: Molecular pain Vol. 8; no. 1; p. 14
• Main Authors: Tochiki, Keri K, Cunningham, Joel, Hunt, Stephen P, Géranton, Sandrine M
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 27.02.2012; BioMed Central Ltd; Sage Publications Ltd; BioMed Central; SAGE Publishing
• Subjects: Animals; Ankle; Ankle Joint - drug effects; Ankle Joint - metabolism; Arthralgia - chemically induced; Arthralgia - metabolism; Astrocyte; Chronic pain; DNA methylation; DNA methyltransferase; Freund's Adjuvant - toxicity; Gene expression; Genetic aspects; Histone deacetylase; Histone Deacetylases - metabolism; Immunohistochemistry; Inflammation; Kinases; MeCP2; Methyl-CpG-Binding Protein 2 - genetics; Methyl-CpG-Binding Protein 2 - metabolism; Methyltransferases; Microglia; Microscopy; Microscopy, Confocal; Multivariate analysis; Neuralgia; Pain; Physiological aspects; Posterior Horn Cells - metabolism; Rats; Reverse Transcriptase Polymerase Chain Reaction; Risk factors; Rodents; Spinal cord; Spinal nerve injury; United Kingdom; MeCP2; Histone deacetylase; Spinal nerve injury; DNA methyltransferase; Inflammation; Astrocyte; Chronic pain; Microglia

Background: DNA CpG methylation is carried out by DNA methyltransferases and induces chromatin remodeling and gene silencing through a transcription repressor complex comprising the methyl-CpG-binding protein 2 (MeCP2) and a subset of histone deacetylases. Recently, we have found that MeCP2 activity...