Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study

• Published in: BMJ Vol. 332; no. 7539; pp. 455 - 458
• Main Authors: Ancelin, Marie L, Artero, Sylvaine, Portet, Florence, Dupuy, Anne-Marie, Touchon, Jacques, Ritchie, Karen
• Format: Journal Article
• Language: English
• Published: London British Medical Journal Publishing Group 25.02.2006; British Medical Association; BMJ Publishing Group LTD; BMJ Publishing Group; BMJ Publishing Group Ltd
• Edition: International edition
• Subjects: Aged; Aged, 80 and over; Analgesics; Antiarrhythmics; Anticholinergics; Antihypertensives; Attention; Attention - drug effects; Biological and medical sciences; Cholinergic agents; Cholinergic Antagonists; Cholinergic Antagonists - adverse effects; Cognition & reasoning; Cognition Disorders; Cognition Disorders - chemically induced; Cognition Disorders - diagnosis; Cognitive impairment; Dementia; Dementia - chemically induced; Dementia - diagnosis; Dementia - epidemiology; Drug therapy; Epidemiologic Methods; France; France - epidemiology; General aspects; Geriatrics; Humans; Inhibitor drugs; Language Disorders; Language Disorders - chemically induced; Language Disorders - epidemiology; Life Sciences; Medical sciences; Memory; Memory Disorders; Memory Disorders - chemically induced; Memory Disorders - epidemiology; Middle Aged; Miscellaneous; Neurology; Neuropsychological Tests; Older adults; Prescription drugs; Public health. Hygiene; Public health. Hygiene-occupational medicine; Reaction Time; Reaction Time - drug effects; Research Support, Non-U.S. Gov't; Santé publique et épidémiologie; Space Perception - drug effects; Thinking - drug effects; France; Montpellier France; Human; Medicine; Drug; Cognitive disorder; Follow up study; Cohort study; Use; mild cognitive impairment; Anticholinesterase agent; Elderly; Parasympatholytic; Public health

Objective To assess the potential of anticholinergic drugs as a cause of non-degenerative mild cognitive impairment in elderly people. Design Longitudinal cohort study. Setting 63 randomly selected general practices in the Montpellier region of southern France. Participants 372 people aged > 60 y...