Deletion of human metapneumovirus M2-2 increases mutation frequency and attenuates growth in hamsters

• Published in: Virology journal Vol. 5; no. 1; p. 69
• Main Authors: Schickli, Jeanne H, Kaur, Jasmine, MacPhail, Mia, Guzzetta, Jeanne M, Spaete, Richard R, Tang, Roderick S
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.06.2008; BioMed Central; BMC
• Subjects: Animals; Base Sequence; Cell Line; Cercopithecus aethiops; Cricetinae; Gene Expression Regulation, Viral; Genetic aspects; Genetic transcription; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Health aspects; Human metapneumovirus; Humans; Mesocricetus; Metapneumovirus - genetics; Metapneumovirus - growth & development; Metapneumovirus - physiology; Mutation; Paramyxoviridae Infections - virology; Paramyxoviruses; Prevention; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - metabolism; Risk factors; RNA virus infections; Vero Cells; Viral Proteins - genetics; Viral Proteins - metabolism; Viral Vaccines - administration & dosage; Virus Replication; United States

Human metapneumovirus (hMPV) infection can cause acute lower respiratory tract illness in infants, the immunocompromised, and the elderly. Currently there are no licensed preventative measures for hMPV infections. Using a variant of hMPV/NL/1/00 that does not require trypsin supplementation for grow...