Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever

• Published in: Virology journal Vol. 7; no. 1; p. 240
• Main Authors: Gowen, Brian B, Julander, Justin G, London, Nyall R, Wong, Min-Hui, Larson, Deanna, Morrey, John D, Li, Dean Y, Bray, Mike
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.09.2010; BioMed Central; BMC
• Subjects: animal models; Animals; Arenavirus; blood serum; Cali mammarenavirus; Capillary Permeability - physiology; Colleges & universities; color; Control; Cricetinae; Cytokines - blood; death; Disease; Disease Models, Animal; dyes; Evans Blue - pharmacokinetics; Female; Fever; Hematocrit; Hemorrhagic fever; Hemorrhagic Fevers, Viral - pathology; Hemorrhagic Fevers, Viral - physiopathology; hypotension; intravenous injection; Laboratory animals; Mesocricetus; Permeability; Pichinde virus; Pichinde virus - pathogenicity; Risk factors; RNA; RNA viruses; Rodents; serum albumin; Serum Albumin - analysis; viremia; virus replication

A number of RNA viruses cause viral hemorrhagic fever (VHF), in which proinflammatory mediators released from infected cells induce increased permeability of the endothelial lining of blood vessels, leading to loss of plasma volume, hypotension, multi-organ failure, shock and death. The optimal trea...