Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy

• Published in: Journal of medical genetics Vol. 50; no. 9; pp. 599 - 605
• Main Authors: Leandro-García, Luis J, Inglada-Pérez, Lucía, Pita, Guillermo, Hjerpe, Elisabet, Leskelä, Susanna, Jara, Carlos, Mielgo, Xabier, González-Neira, Anna, Robledo, Mercedes, Åvall-Lundqvist, Elisabeth, Gréen, Henrik, Rodríguez-Antona, Cristina
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd 01.09.2013; BMJ Publishing Group LTD
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Axon guidance; Cancer therapies; Carboplatin; Cell division; Chemotherapy; Drug dosages; EphA4 protein; Farmakologi och toxikologi; Female; Genetic diversity; Genetic Predisposition to Disease; Genetics; Genome-wide; Genome-wide association studies; Genome-Wide Association Study; Genome-wide studies; Genomes; Humans; Kaplan-Meier Estimate; Klinisk medicin; Male; MEDICIN; Medicin och hälsovetenskap; MEDICINE; Medicinska och farmaceutiska grundvetenskaper; Meta-analysis; Middle Aged; Molecular genetics; Neoplasms - drug therapy; Neurologi; Neurotoxicity; Oncology; Ovaries; Paclitaxel; Paclitaxel - adverse effects; Paclitaxel - therapeutic use; Peripheral nerve disease; Peripheral Nervous System Diseases - chemically induced; Peripheral Nervous System Diseases - genetics; Peripheral neuropathy; Polymorphism, Single Nucleotide; Receptors, Eph Family - genetics; Single-nucleotide polymorphism; Software; Solid tumors; Statistical analysis; Toxicity; United States > US; Genetics; Oncology; Genome-wide; Peripheral nerve disease; Molecular genetics

Background Peripheral neuropathy is the dose limiting toxicity of paclitaxel, a chemotherapeutic drug widely used to treat solid tumours. This toxicity exhibits great inter-individual variability of unknown origin. The present study aimed to identify genetic variants associated with paclitaxel induc...