P343 Lower psoas muscle density, a proxy for sarcopenia, associates with 30-day mortality in patients with acute variceal bleeding

IntroductionAcute variceal bleeding (AVB) is associated with high mortality in patients with cirrhosis. Liver function is inversely associated with outcome after AVB; higher disease severity scores are associated with higher 30-day mortality. Sarcopenia is associated with increased mortality in cirr...

Full description

Saved in:
Bibliographic Details
Published inGut Vol. 73; no. Suppl 1; p. A260
Main Authors Leon, Dylan, Tyson, Luke, Krawczyk, Jedrzej, Haq, Taha, Saba, Dana, Thomas, Robert, Dhar, Ameet
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.06.2024
BMJ Publishing Group LTD
Subjects
Online AccessGet full text

Cover

Loading…
Abstract IntroductionAcute variceal bleeding (AVB) is associated with high mortality in patients with cirrhosis. Liver function is inversely associated with outcome after AVB; higher disease severity scores are associated with higher 30-day mortality. Sarcopenia is associated with increased mortality in cirrhosis, but it is unclear whether sarcopenia is an independent risk factor for mortality after AVB. This service evaluation aimed to identify factors associated with mortality after AVB, including measures of psoas muscle density as a proxy for sarcopenia.MethodsPatients admitted to Imperial College Healthcare Trust hospitals with suspected AVB 01/05/2020 to 30/09/2022 were retrospectively included. Baseline demographics, clinical parameters, interventions, and outcome measures including 30-day mortality were recorded. Psoas muscle measurements were made from CT scans within 3-months of AVB. Associations were tested by binary logistic regression; correlation by Spearman’s Rank; p-values were adjusted for multiple comparisons by the Benjamini-Hochberg procedure.ResultsOf 120 suspected AVB, 104 were confirmed endoscopically. In suspected AVB, baseline MELD (odds ratio, OR 1.15, 1.07–1.12, P = 0.001), serum bilirubin (OR 1.01, 1.00–1.01, P = 0.004), serum albumin (OR 0.87, 0.79–0.95, P = 0.02), administration of clotting products (OR = 5.18, 1.68- 15.93, P=0.027) and Psoas HU (0.93, 0.88–0.98, P=0.044) were associated with 30-day mortality. Baseline serum albumin and Psoas Hu were associated with mortality when adjusted for baseline MELD (adjusted OR, AOR 0.903, 0.816–0.998, P = 0.046; AOR 0.920, 0.861–0.982, P = 0.036, respectively). As a sensitivity analysis, only patients with a CT scan within seven days after a confirmed variceal bleed were included (54 patients; 5 deaths): Psoas HU remained significantly associated with mortality independent of MELD (AOR 0.893, 0.809 - 0.986, P = 0.025). Psoas HU did not correlate with MELD or bilirubin.ConclusionsLower psoas muscle HU, a recognised measure of psoas muscle density and nutritional status, is associated with higher 30-day mortality post AVB independent of baseline liver disease severity, represented by MELD score. This association should be confirmed prospectively. If confirmed, early nutritional intervention could be trialled in at risk patients post AVB.
AbstractList IntroductionAcute variceal bleeding (AVB) is associated with high mortality in patients with cirrhosis. Liver function is inversely associated with outcome after AVB; higher disease severity scores are associated with higher 30-day mortality. Sarcopenia is associated with increased mortality in cirrhosis, but it is unclear whether sarcopenia is an independent risk factor for mortality after AVB. This service evaluation aimed to identify factors associated with mortality after AVB, including measures of psoas muscle density as a proxy for sarcopenia.MethodsPatients admitted to Imperial College Healthcare Trust hospitals with suspected AVB 01/05/2020 to 30/09/2022 were retrospectively included. Baseline demographics, clinical parameters, interventions, and outcome measures including 30-day mortality were recorded. Psoas muscle measurements were made from CT scans within 3-months of AVB. Associations were tested by binary logistic regression; correlation by Spearman’s Rank; p-values were adjusted for multiple comparisons by the Benjamini-Hochberg procedure.ResultsOf 120 suspected AVB, 104 were confirmed endoscopically. In suspected AVB, baseline MELD (odds ratio, OR 1.15, 1.07–1.12, P = 0.001), serum bilirubin (OR 1.01, 1.00–1.01, P = 0.004), serum albumin (OR 0.87, 0.79–0.95, P = 0.02), administration of clotting products (OR = 5.18, 1.68- 15.93, P=0.027) and Psoas HU (0.93, 0.88–0.98, P=0.044) were associated with 30-day mortality. Baseline serum albumin and Psoas Hu were associated with mortality when adjusted for baseline MELD (adjusted OR, AOR 0.903, 0.816–0.998, P = 0.046; AOR 0.920, 0.861–0.982, P = 0.036, respectively). As a sensitivity analysis, only patients with a CT scan within seven days after a confirmed variceal bleed were included (54 patients; 5 deaths): Psoas HU remained significantly associated with mortality independent of MELD (AOR 0.893, 0.809 - 0.986, P = 0.025). Psoas HU did not correlate with MELD or bilirubin.ConclusionsLower psoas muscle HU, a recognised measure of psoas muscle density and nutritional status, is associated with higher 30-day mortality post AVB independent of baseline liver disease severity, represented by MELD score. This association should be confirmed prospectively. If confirmed, early nutritional intervention could be trialled in at risk patients post AVB.
Author Dhar, Ameet
Haq, Taha
Saba, Dana
Krawczyk, Jedrzej
Thomas, Robert
Leon, Dylan
Tyson, Luke
Author_xml – sequence: 1
  givenname: Dylan
  surname: Leon
  fullname: Leon, Dylan
  organization: Imperial College London, London, UK
– sequence: 2
  givenname: Luke
  surname: Tyson
  fullname: Tyson, Luke
  organization: Imperial College Healthcare NHS Trust, London, UK
– sequence: 3
  givenname: Jedrzej
  surname: Krawczyk
  fullname: Krawczyk, Jedrzej
  organization: Imperial College Healthcare NHS Trust, London, UK
– sequence: 4
  givenname: Taha
  surname: Haq
  fullname: Haq, Taha
  organization: Imperial College Healthcare NHS Trust, London, UK
– sequence: 5
  givenname: Dana
  surname: Saba
  fullname: Saba, Dana
  organization: Imperial College Healthcare NHS Trust, London, UK
– sequence: 6
  givenname: Robert
  surname: Thomas
  fullname: Thomas, Robert
  organization: Imperial College Healthcare NHS Trust, London, UK
– sequence: 7
  givenname: Ameet
  surname: Dhar
  fullname: Dhar, Ameet
  organization: Imperial College Healthcare NHS Trust, London, UK
BookMark eNpFkE1Lw0AQhhdRsK3-Ai8LXk07-5Ht5qhFq1BQsPewSSY1Id2t2Y21Nw_6R_0lprTgaeDlmXmZZ0hOrbNIyBWDMWNCTVZdqG0TceAyunudjyWPT8iASaUjwbU-JQMANo3iqUzOydD7GgC0TtiAfL8IKX6_fhZuiy3deGc8XXc-b5AWaH0VdjfU0E3rPne0dC31ps3dBm1l-tx7l1cmoKfbKrxRAVFhdnTt2mCafpNWlm5MqNCGI2HyLiD9MG2Vo2lo1iAWlV1dkLPSNB4vj3NElg_3y9ljtHieP81uF1GmdBKpgoNSEDMJGSBgxjkmuRBKxqaMcy4RTaZQFVIg5ExM0aBAzIpElsg0ihG5Ppzt33nv0Ie0dl1r-8ZUgI45MJ0kPTU5UNm6_gcYpHvT6cF0ujed9qbT3rT4A7P3d_Q
ContentType Journal Article
Copyright Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.
2024 Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.
Copyright_xml – notice: Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.
– notice: 2024 Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.
DBID K9.
DOI 10.1136/gutjnl-2024-BSG.425
DatabaseName ProQuest Health & Medical Complete (Alumni)
DatabaseTitle ProQuest Health & Medical Complete (Alumni)
DatabaseTitleList ProQuest Health & Medical Complete (Alumni)

DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1468-3288
EndPage A260
ExternalDocumentID gutjnl
GroupedDBID ---
.55
.GJ
.VT
08G
0R~
18M
29I
2WC
354
39C
3O-
3V.
4.4
40O
53G
5GY
5VS
7X7
7~S
88E
88I
8AF
8F7
8FE
8FH
8FI
8FJ
8R4
8R5
AAHLL
AAKAS
AAOJX
AAUVZ
AAWJN
AAYEP
ABAAH
ABJNI
ABKDF
ABMQD
ABOCM
ABTFR
ABUWG
ABVAJ
ACGFO
ACGFS
ACGOD
ACGTL
ACHTP
ACMFJ
ACOFX
ACTZY
ADBBV
ADCEG
ADFRT
ADUGQ
ADZCM
AENEX
AFKRA
AFWFF
AHMBA
AHNKE
AHQMW
AI.
AJYBZ
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ASPBG
AVWKF
AZFZN
AZQEC
BAWUL
BBNVY
BENPR
BHPHI
BLJBA
BOMFT
BPHCQ
BTFSW
BTHHO
BVXVI
C1A
C45
CAG
CCPQU
COF
CS3
CXRWF
DIK
DU5
DWQXO
E3Z
EBS
EJD
F5P
FD8
FEDTE
FYUFA
GNUQQ
GX1
H13
HAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
IAO
IEA
IH2
IHR
INH
INR
IOF
ITC
J5H
KQ8
L7B
LK8
M1P
M2P
M7P
N9A
NTWIH
NXWIF
O9-
OK1
OVD
P2P
PQQKQ
PROAC
PSQYO
Q2X
R53
RHF
RHI
RMJ
RPM
RV8
TEORI
TR2
UKHRP
UYXKK
V24
VH1
VM9
VVN
W8F
WH7
WOQ
X7M
YFH
YOC
YQY
ZGI
ZXP
ZY1
K9.
ID FETCH-LOGICAL-b689-6d206605140b0e0eb22e9c33645af5c24eeab6e6d43e0c137eae3eebd94fe18e3
ISSN 0017-5749
IngestDate Fri Nov 29 04:15:03 EST 2024
Tue Nov 26 16:40:47 EST 2024
IsPeerReviewed true
IsScholarly true
Issue Suppl 1
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-b689-6d206605140b0e0eb22e9c33645af5c24eeab6e6d43e0c137eae3eebd94fe18e3
Notes BSG LIVE’24, 17-20 June 2024, ICC Birmingham
PQID 3085201899
PQPubID 2041069
ParticipantIDs proquest_journals_3085201899
bmj_journals_10_1136_gutjnl_2024_BSG_425
PublicationCentury 2000
PublicationDate 20240600
20240601
PublicationDateYYYYMMDD 2024-06-01
PublicationDate_xml – month: 06
  year: 2024
  text: 20240600
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle Gut
PublicationTitleAbbrev Gut
PublicationYear 2024
Publisher BMJ Publishing Group Ltd and British Society of Gastroenterology
BMJ Publishing Group LTD
Publisher_xml – name: BMJ Publishing Group Ltd and British Society of Gastroenterology
– name: BMJ Publishing Group LTD
SSID ssj0008891
Score 2.4978142
Snippet IntroductionAcute variceal bleeding (AVB) is associated with high mortality in patients with cirrhosis. Liver function is inversely associated with outcome...
SourceID proquest
bmj
SourceType Aggregation Database
Publisher
StartPage A260
SubjectTerms Albumin
Bilirubin
Bleeding
Cirrhosis
Clotting
Computed tomography
Liver cirrhosis
Liver diseases
Mortality
Nutritional status
Patients
Poster Presentations
Proteins
Psoas muscle
Risk factors
Sarcopenia
Sensitivity analysis
Title P343 Lower psoas muscle density, a proxy for sarcopenia, associates with 30-day mortality in patients with acute variceal bleeding
URI https://gut.bmj.com/content/73/Suppl_1/A260.1.full
https://www.proquest.com/docview/3085201899
Volume 73
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6lqYS4IJ6iUKo9cEAKDsnuxo9jCyVVSaoKgpSbtWuvC2niQByDkhMH-KP9Jcy-7FTpoXCxkpUf8szn3dndb75B6CWhyrE89SSF8I1FPvEiFglP8MwnnAvu91Ry8vDMP_nMTse9caNxtcFaKpeinaxvzCv5H69CG_hVZcn-g2erm0ID_Ab_whE8DMdb-ficMmrZCmFvoOqdtb4Vc160ZmWR6Iyo3Kn-85YmrGhWYQHgVlWzDE-WWwdJm-hGO57KDZnpuFzF6LX6qkuFSxS54AdXekTgYTHdGAFtnNsvKzrNQJqN_XeraY3E0cpmeg3KywpaHxb8Z7JeXRrWTbpYy0ndQX7XyOJf-OY6BWE1n8osxg1Pt1bWFHNJ75E4ASfHVIU4uc-L5WKudEkX9f6C7cRhYO0FRum0LU2_rRLIKDEVAl3HbmqkWADrIqmt7kZffUhMJQM77ru_22OKLnpzUS4n-dTTb3b0qd9mJl_7uoL3hTXudQVvc-kO2lVijayJdo-Oz84_VvFC6Oo62tey2ljw2Dc3PBRiIDGbbEUOOhwa3Uf37DwGHxpQPkANmT9Ed4aWqfEI_VbYvPr1R6MSa1Rig0psUfkac6wxiQGTuMYktFeIxApv2CASV4jEX3PsEGnO0IjEDpHYIfIxGr0_Hr098WzFD0_4YeT5qSouoBT5O6IjO1IQIqOEqp1ynvUSwqTkwpd-yqjsJF0aSC6plCKNWCa7oaRPUDOf5_IpwkGWiiSIUiJIwniahVEoqEjhGjX8J9099ArMGNuPuYj1XJj6sbF4rCweg8VjsPge2ne2rs-nMFWB2DmMome3v9NzdLf-MvZRc7ko5QuIaZfiAO0E4-DAQuMv_siqnA
link.rule.ids 314,780,784,27924,27925,31719,33744
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=P343%E2%80%85Lower+psoas+muscle+density%2C+a+proxy+for+sarcopenia%2C+associates+with+30-day+mortality+in+patients+with+acute+variceal+bleeding&rft.jtitle=Gut&rft.au=Leon%2C+Dylan&rft.au=Tyson%2C+Luke&rft.au=Krawczyk%2C+Jedrzej&rft.au=Haq%2C+Taha&rft.date=2024-06-01&rft.pub=BMJ+Publishing+Group+Ltd+and+British+Society+of+Gastroenterology&rft.issn=0017-5749&rft.eissn=1468-3288&rft.volume=73&rft.issue=Suppl+1&rft.spage=A260&rft.epage=A260&rft_id=info:doi/10.1136%2Fgutjnl-2024-BSG.425&rft.externalDBID=gut&rft.externalDocID=gutjnl
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0017-5749&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0017-5749&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0017-5749&client=summon