Tumor suppressor genes are frequently methylated in lymph node metastases of breast cancers

• Published in: BMC cancer Vol. 10; no. 1; p. 378
• Main Authors: Feng, Weiwei, Orlandi, Rosaria, Zhao, Naiqing, Carcangiu, Maria Luisa, Tagliabue, Elda, Xu, Jia, Bast, Jr, Robert C, Yu, Yinhua
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.07.2010; BioMed Central; BMC
• Subjects: Adult; Aged; Breast - metabolism; Breast - pathology; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cadherins - genetics; Carcinoma, Ductal, Breast - genetics; Carcinoma, Ductal, Breast - secondary; Carcinoma, Lobular - genetics; Carcinoma, Lobular - secondary; Case-Control Studies; Cytokines - genetics; Development and progression; DNA damage; DNA Methylation; DNA-Binding Proteins - genetics; Female; Genes, Tumor Suppressor; Genetic aspects; Humans; Immunoenzyme Techniques; LIM Domain Proteins; Lymphatic metastasis; Middle Aged; Neoplasm Staging; Physiological aspects; Polymerase Chain Reaction; Prognosis; Promoter Regions, Genetic - genetics; Receptors, Estrogen - metabolism; Receptors, Retinoic Acid - genetics; Risk factors; Tumor suppressor genes; Tumor Suppressor Proteins - genetics; United States; China

Metastasis represents a major adverse step in the progression of breast carcinoma. Lymph node invasion is the most relevant prognostic factor; however little is known on the molecular events associated with lymph node metastasis process. This study is to investigate the status and role of methylatio...