Seladin-1 expression is regulated by promoter methylation in adrenal cancer

• Published in: BMC cancer Vol. 10; no. 1; p. 201
• Main Authors: Simi, Lisa, Malentacchi, Francesca, Luciani, Paola, Gelmini, Stefania, Deledda, Cristiana, Arvia, Rosaria, Mannelli, Massimo, Peri, Alessandro, Orlando, Claudio
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.05.2010; BioMed Central; BMC
• Subjects: Adrenal Gland Neoplasms - enzymology; Adrenal Gland Neoplasms - genetics; Azacitidine - analogs & derivatives; Azacitidine - pharmacology; Carcinoma - enzymology; Carcinoma - genetics; Cell Line, Tumor; DNA Methylation - drug effects; DNA Modification Methylases - antagonists & inhibitors; DNA Modification Methylases - metabolism; Enzyme Inhibitors - pharmacology; Enzyme kinetics; Epigenesis, Genetic - drug effects; Gene expression; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Observations; Oxidoreductases Acting on CH-CH Group Donors - genetics; Oxidoreductases Acting on CH-CH Group Donors - metabolism; Physiological aspects; Polymerase Chain Reaction; Promoter Regions, Genetic - drug effects; RNA, Messenger - metabolism; Time Factors; Italy

Seladin-1 overexpression exerts a protective mechanism against apoptosis. Seladin-1 mRNA is variably expressed in normal human tissues. Adrenal glands show the highest levels of seladin-1 expression, which are significantly reduced in adrenal carcinomas (ACC). Since up to now seladin-1 mutations wer...